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A DYSTROPHIN HOMOLOG ON THE SURFACE-MEMBRANE OF EMBRYONIC AND DENERVATED MDX MOUSE MUSCLE-FIBERS

被引：5
|
作者：
TAKEMITSU, M [1 ]
ISHIURA, S [1 ]
KOGA, R [1 ]
ARAHATA, K [1 ]
NONAKA, I [1 ]
SUGITA, H [1 ]
机构：
[1] ASAHIKAWA MED COLL,DEPT ORTHOPAED SURG,ASAHIKAWA,HOKKAIDO 078,JAPAN
来源：
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES | 1991年 / 67卷 / 07期
关键词：
DYSTROPHIN; DYSTROPHIN-RELATED PROTEIN; MDX MOUSE; IMMUNOHISTOCHEMISTRY; MUSCLE SURFACE MEMBRANE;
D O I：
10.2183/pjab.67.125
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
With immunohistochemical staining using polyclonal antibodies against the carboxyl terminus of a dystrophin molecule, the surface membranes of fetal and denervated adult muscle fibers and the neuromuscular junctions in dystrophin deficient mdx mice showed positive immunoreactivity. The behavior of the positively stained protein was similar to that of the acetylcholine receptor. We conclude that this immunoreactive protein, probably a dystrophin-related protein, plays a role in the assembly of junctional proteins.
引用
收藏
页码：125 / 128
页数：4
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