POLY(ADP-RIBOSE) CATABOLISM IN MAMMALIAN-CELLS

被引：12
|
作者：
LAGUEUX, J [1 ]
SHAH, GM [1 ]
MENARD, L [1 ]
THOMASSIN, H [1 ]
DUCHAINE, C [1 ]
HENGARTNER, C [1 ]
POIRIER, GG [1 ]
机构：
[1] CHUL,RES CTR,MOLEC ENDOCRINOL RES CTR,POLYADP RIBOSE METAB GRP,ST FOY G1V 4G2,PQ,CANADA
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 1994年 / 138卷 / 1-2期
关键词：
POLY(ADP-RIBOSE) METABOLISM; TURNOVER; CHROMATIN; DNA-REPAIR; HISTONES;
D O I：
10.1007/BF00928442
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Poly(ADP-ribose) catabolism is a complex situation involving many proteins and DNA. We have developed an in vitro turnover system where poly(ADP-ribose) metabolism is monitored in presence of different relative amounts of two principal enzymes poly(ADP-ribose) transferase and poly(ADP-ribose) glycohydrolase along with other proteins and DNA. Our current results reviewed here show that the quality of polymer, i.e. chain length and complexity, as well as preference for the nuclear substrate varies depending upon the availability of poly(ADP-ribose) glycohydrolase. These results are interpreted in the light of the recent data implicating poly(ADP-ribose) metabolism in DNA-repair.
引用
收藏
页码：45 / 52
页数：8
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