EFFECTS OF AMIDATED RAT ISLET AMYLOID POLYPEPTIDE ON GLUCOSE-STIMULATED INSULIN-SECRETION INVIVO AND INVITRO IN RATS

被引：34
|
作者：
ARRAJAB, A
AHREN, B
机构：
[1] UNIV LUND,DEPT PHARMACOL,SOLVEGATAN 10,S-22362 LUND,SWEDEN
[2] UNIV LUND,DEPT SURG,S-22362 LUND,SWEDEN
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 192卷 / 03期
关键词：
ISLET AMYLOID POLYPEPTIDE; INSULIN SECRETION; (INVIVO); (INVITRO); (RAT);
D O I：
10.1016/0014-2999(91)90239-M
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Amidated rat islet amyloid polypeptide (IAPP) is a constituent of secretory granules in islet B-cells. We examined its influence on glucose-stimulated insulin secretion in rats. In vivo, intravenous infusion of IAPP (68 pmol/min) did not affect glucose-stimulated insulin secretion. In vitro, IAPP slightly inhibited glucose (8.3 mM)-stimulated insulin secretion from isolated rat islets at the high dose level of 10(-5) M but not at the lower dose levels. We conclude that the IAPP is not involved in the normal regulation of insulin secretion.
引用
收藏
页码：443 / 445
页数：3
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