PHASE-II TRIAL OF TOPOTECAN IN PATIENTS WITH ADVANCED RENAL-CELL CARCINOMA

被引：29
|
作者：
LAW, TM [1 ]
ILSON, DH [1 ]
MOTZER, RJ [1 ]
机构：
[1] MEM SLOAN KETTERING CANC CTR,DEPT MED,DIV SOLID TUMOR ONCOL,GENITOURINARY ONCOL SERV,NEW YORK,NY 10021
来源：
INVESTIGATIONAL NEW DRUGS | 1994年 / 12卷 / 02期
关键词：
TOPOTECAN; RENAL CELL CARCINOMA;
D O I：
10.1007/BF00874445
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Fifteen patients with advanced renal cell carcinoma were treated on a phase II trial with topotecan. None of the fourteen evaluable patients achieved a complete or partial response. Myelosuppression was the most common toxicity. Eighty percent (12 of 15) of patients experienced grade III or IV neutropenia and/or anemia. Topotecan is not efficacious in the treatment of advanced renal cell carcinoma.
引用
收藏
页码：143 / 145
页数：3
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