Cancer incidence and cause‐specific mortality were studied in a male cohort of 94 talc miners and 295 talc millers, exposed to non‐asbestiform talc with low quartz content. No excess risk was found compared with national age‐specific incidence. Six cases of lung cancer occurred versus 6.49 expected (miners: observed 2, expected 1.27; millers: observed 4, expected 5.22). There were 3 deaths due to non‐malignant respiratory disease against 10.9 expected (miners: observed 1, expected 2.5; millers: observed 2, expected 8.4). Mesothelioma, tuberculosis, or pneumoconiosis were not recorded as causes of death. Pneumoconiosis was noted as a contributory cause in three cases (silicosis two, talcosis one). Further follow‐up will reduce any potential impact of “healthy worker” selection. Copyright © 1990 Wiley Periodicals, Inc., A Wiley Company