THE EFFECT OF ASPIRIN ON REPRODUCTIVE ORGANS OF FEMALE ALBINO RAT

被引：1
|
作者：
Jain, Neha [1 ]
Shrivastava, Renu [1 ]
Raghuwanshi, Arun K. [1 ]
Shrivastava, Vinoy K. [1 ]
机构：
[1] Barkatullah Univ, Dept Biosci, Lab Endocrinol, Bhopal 462026, Madhya Pradesh, India
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2012年 / 3卷 / 08期
关键词：
Aspirin (acetylsalicylic acid; ASA); Enzymological estimations; Histopathological variations; Rattus norvegicus;
D O I：
10.13040/IJPSR.0975-8232.3(8).2644-47
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The aim of present investigation is to study the effect of oral administration of drug acetylsalicylic acid (ASA, aspirin) on female albino rat, Rattus norvegicus. The female rats (n=24) were allocated into 2 groups as control (n=12) and treated (n=12). The treated rats were given oral dose of aspirin 100 mg/kg body weight for 15 days (n=6) and 30 days (n=6). Tissues enzymological estimations such as ACP (Acid Phosphatase) and ALP (Alkaline Phosphatase) along with histopathological studies of reproductive organs (ovary and uterus) were done. The present investigation indicated that, aspirin significantly increased ACP and ALP content in reproductive tissues and also caused significant histopathological variations in reproductive organs such as ovary and uterus by modulating certain enzyme metabolism in female albino rats.
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页码：2644 / 2647
页数：4
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