EUGLYCEMIC AND BIOLOGICAL-ACTIVITIES OF NOVEL THIAZOLIDINE-2,4-DIONE DERIVATIVES

被引：0
|
作者：
DENANTEUIL, G
HERVE, Y
DUHAULT, J
ESPINAL, J
BOULANGER, M
RAVEL, D
机构：
[1] INST RECH SERVIER,DIV MED CHEM,F-92150 SURESNES,FRANCE
[2] INST RECH SERVIER,DIV METAB DIS,F-92150 SURESNES,FRANCE
来源：
ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH | 1995年 / 45-2卷 / 11期
关键词：
DIABETES MELLITUS; NON-INSULIN DEPENDENT; INSULIN RESISTANCE; THIAZOLIDINE-2,4-DIONE DERIVATIVES;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new series of thiazolidine-2,4-dione derivatives was obtained by incorporating one or the other of the two carbons of the central chain into different rings. These con?pounds lower blood glucose levels in the genetically obese and insulin-resistant oblob mouse. Moreover, they decreased insulin and triglyceride levels in the Zucker falfa rat. Incorporation of the left hand carbon of the chain afforded compounds among which pyrrolidino derivatives 5, 9 and 13 were the most potent. The same carbon atom was used to elaborate different types of rings (benzocyclobutane, benzodioxane), giving rise to compounds 14 and 19 with moderate to goon activity. Finally cyclization using the right hand cat bon of the chain gave rise to highly potent benzofurane 24.
引用
收藏
页码：1176 / 1181
页数：6
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