IMPACT OF TUMOR-NECROSIS-FACTOR-ALPHA AND INTERFERON-GAMMA ON TETRAHYDROBIOPTERIN SYNTHESIS IN MURINE FIBROBLASTS AND MACROPHAGES

被引：53
|
作者：
WERNER, ER
WERNERFELMAYER, G
FUCHS, D
HAUSEN, A
REIBNEGGER, G
YIM, JJ
WACHTER, H
机构：
[1] UNIV INNSBRUCK, INST MED CHEM & BIOCHEM, FRITZ PREGL STR 3, A-6020 INNSBRUCK, AUSTRIA
[2] SEOUL NATL UNIV, DEPT MICROBIOL, SEOUL 151, SOUTH KOREA
来源：
BIOCHEMICAL JOURNAL | 1991年 / 280卷
关键词：
D O I：
10.1042/bj2800709
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tumour necrosis factor-alpha causes an up to 30-fold induction of GTP cyclohydrolase I (EC 3.5.4.16) activity in murine dermal fibroblasts in a dose-dependent manner. Owing to the high constitutive activities of 6-pyruvoyltetrahydropterin synthase and sepiapterin reductase (EC 1.1.1.153), this potentiates biosynthesis of tetrahydrobiopterin. Murine macrophages already contain high activities of GTP cyclohydrolase I when unstimulated, and this is further augmented up to 4-fold by tumour necrosis factor-alpha/interferon-gamma. In Western blots an antiserum to murine liver GTP cyclohydrolase I does not stain cell extracts with high enzyme activities, suggesting that the cytokine induced peripheral form of GTP cyclohydrolase I might differ from the liver form.
引用
收藏
页码：709 / 714
页数：6
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