TIME-DEPENDENT CADMIUM-NEUROTOXICITY IN RAT-BRAIN SYNAPTOSOMAL PLASMA-MEMBRANES

被引：20
|
作者：
FASITSAS, CD
THEOCHARIS, SE
ZOULAS, D
CHRISSIMOU, S
DELICONSTANTINOS, G
机构：
[1] Department of Experimental Physiology, School of Medicine, University of Athens
来源：
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1991年 / 100卷 / 1-2期
关键词：
D O I：
10.1016/0742-8413(91)90167-R
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
1. The modulation of lipid dynamics and lipid protein interactions were studied in rat brain synaptosomal plasma membranes (SPM) up to 24 hr after exposure to cadmium (Cd). 2. The activity of acetylcholinesterase and adenylate cyclase showed a considerable decrease after 6 hr of Cd exposure, followed by a progressive increase up to 24 hr. 3. SPM chemiluminescence showed a maximum decrease at 12 hr, demonstrating a considerable increase in lipid peroxidation. 4. SPM of Cd-exposed animals showed a statistical significant increase in fluorescence anisotropy parameter [(r0/r) - 1]-1 at 18 and 24 hr compared to SPM of the control, indicating a decrease of membrane fluidity.
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页码：271 / 275
页数：5
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