ORAL-THERAPY OF NONINSULIN-DEPENDENT DIABETES-MELLITUS

The paper presents the results obtained in the treatment of 510 patients with noninsulin-dependent diabetes mellitus (NIDDM). Of them 420 received bucarban, 30 gilemal and 60 adebit. Bucarban and gilemal decreased fasting glycemia and that after the standard meal. The patients were also made less insulin-resistant. Hyperinsulinemia did not respond to the above drugs. Adebit demonstrated hypoglycemic, antihyperinsulinemic, antihyperbetalipoproteinemic and hypocholesterolemic activity. 10% of NIDDM patients developed primary resistance to oral sulfonamide drugs. In intact insulin secretion NIDDM patients were effectively treated both with sulfonamide sugar-reducing drugs and biguanid derivatives.