FACIAL MORPHOMETRY OF ECUADORIAN PATIENTS WITH GROWTH-HORMONE RECEPTOR DEFICIENCY LARON SYNDROME

被引：30
|
作者：
SCHAEFER, GB
ROSENBLOOM, AL
GUEVARAAGUIRRE, J
CAMPBELL, EA
ULLRICH, F
PATIL, K
FRIAS, JL
机构：
[1] UNIV FLORIDA, DEPT PEDIAT, GAINESVILLE, FL USA
[2] INST ENDOCRINOL & METAB & REPROD, QUITO, ECUADOR
[3] UNIV NEBRASKA, MED CTR, DEPT BIOSTAT, OMAHA, NE USA
来源：
JOURNAL OF MEDICAL GENETICS | 1994年 / 31卷 / 08期
关键词：
D O I：
10.1136/jmg.31.8.635
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Facial morphometry using computerised image analysis was performed on patients with growth hormone receptor deficiency (Laron syndrome) from an inbred population of southern Ecuador. Morphometrics were compared for 49 patients, 70 unaffected relatives, and 14 unrelated persons. Patients with growth hormone receptor deficiency showed significant decreases in measures of vertical facial growth as compared to unaffected relatives and unrelated persons with short stature from other causes. This report validates and quantifies the clinical impression of foreshortened facies in growth hormone receptor deficiency.
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页码：635 / 639
页数：5
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