Neural Repair and Neuroprotection with Stem Cells in Ischemic Stroke

被引：15
|
作者：
Stone, Laura L. [1 ,2 ,3 ]
Grande, Andy [2 ,3 ]
Low, Walter C. [2 ,3 ]
机构：
[1] Univ Minnesota, Grad Program Neurosci, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Dept Neurosurg, Minneapolis, MN 55455 USA
[3] Univ Minnesota, Stem Cell Inst, Minneapolis, MN 55455 USA
来源：
BRAIN SCIENCES | 2013年 / 3卷 / 02期
关键词：
ischemia; ischemic brain injury; neuroprotection; stem cells; stroke;
D O I：
10.3390/brainsci3020599
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Stem cells have been touted as a potential source of cells for repair in regenerative medicine. When transplanted into the central nervous system, stem cells have been shown to differentiate into neurons and glia. Recent studies, however, have also revealed neuroprotective properties of stem cells. These studies suggest that various types of stem cells are able to protect against the loss of neurons in conditions of ischemic brain injury. In this article, we discuss the use of stem cells for ischemic stroke and the parameters under which neuroprotection can occur in the translation of stem cell therapy to the clinical setting.
引用
收藏
页码：599 / 614
页数：16
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