POLYMERS HAVING (1-]4)-LINKED AND (1-]6)-LINKED ALPHA-D-GLUCOPYRANOSYL GROUPS AS ACCEPTORS IN THE GLYCOGEN-SYNTHASE REACTION

被引:12
|
作者
ZEHAVI, U [1 ]
HERCHMAN, M [1 ]
KOPPER, S [1 ]
机构
[1] HEBREW UNIV JERUSALEM,FAC AGR,DEPT BIOCHEM & HUMAN NUTR,POB 12,IL-76100 REHOVOT,ISRAEL
关键词
D O I
10.1016/S0008-6215(00)90563-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Insoluble, light-sensitive polymers linked to maltose, maltotriose, a glycogen-branch point trisaccharide, and panose were synthesized and served in a comparative study as acceptors in the glycogen synthase (UDP-D-glucose:glycogen 4-alpha-D-glucosyltransferase, EC 2.4.1.11) reaction. The highest transfer rate was observed with the maltotrio polymer. Extending the acceptor linearly with (1 --> 4)-linked alpha-D-glucopyranosyl residues improved the transfer, whereas (1 --> 6)-linked alpha-D-glucopyranosyl branches decreased it.
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页码:255 / 263
页数:9
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