CONCENTRATION-RESPONSE CURVES FOR ETHYLENE-OXIDE-INDUCED HERITABLE TRANSLOCATIONS AND DOMINANT LETHAL MUTATIONS

被引：41
|
作者：
GENEROSO, WM
CAIN, KT
CORNETT, CV
CACHEIRO, NLA
HUGHES, LA
机构：
[1] Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee
来源：
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 1990年 / 16卷 / 02期
关键词：
dominant lethal mutations; ethylene oxide; heritable translocation; mice;
D O I：
10.1002/em.2850160209
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Male mice were subjected to repeated inhalation exposures to different concentrations (165, 204, 250, or 300 ppm) of ethylene oxide (EtO) during an 8.5‐week period. Transmitted clastogenic effects of these exposures were measured in terms of induction of dominant lethal mutations and heritable translocations. The concentration‐response curves for both endpoints are not linear but are markedly concave upward. Significant increases in dominant lethals were detected at all concentrations, except the lowest one. In comparison, the incidences of heritable translocations were significantly increased at all concentrations. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company
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页码：126 / 131
页数：6
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