INVITRO ACTIVITY OF SULBACTAM AMPICILLIN AGAINST AMPICILLIN-RESISTANT, BETA-LACTAMASE-PRODUCING BACTERIA ISOLATED IN ITALIAN HOSPITALS

被引:2
|
作者
VARALDO, PE
RIPA, S
NICOLETTI, G
COVELLI, I
SATTA, G
CARLONE, N
FONTANA, R
机构
[1] UNIV CAMERINO,INST MICROBIOL,I-62032 CAMERINO,ITALY
[2] UNIV CATANIA,INST MICROBIOL,I-95124 CATANIA,ITALY
[3] NAPLES UNIV,INST MICROBIOL,I-80138 NAPLES,ITALY
[4] UNIV SIENA,INST MICROBIOL,I-53100 SIENA,ITALY
[5] UNIV TURIN,INST MICROBIOL,I-10124 TURIN,ITALY
[6] UNIV VERONA,INST MICROBIOL,I-37100 VERONA,ITALY
关键词
ampicillin; antibacterial activity; sulbactam; β-lactamase inhibition;
D O I
10.1159/000238760
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A multicenter study aimed at assessing the in vitro activity of sulbactam/ampicillin against a wide range of bacterial pathogens was performed using 2,209 clinical strains, all recently collected from inpatients in seven Italian centers and preliminarily screened as being ampicillin-resistant and β-lactamase producers. In comparative disk diffusion trials using 8 large-spectrum antimicrobials, the percentage of resistance to sulbactam/ampicillin in staphylococci was similar to the percentage of resistance to netilmicin and lower than to the other antibiotics; with gram-negative bacteria, only netilmicin, ofloxacin, and, less consistently, cefotetan showed lower incidences of resistance. The minimal inhibitory concentrations (MICs) of ampicillin alone and sulbactam/ampicillin together were determined using the agar dilution method. The Enterobacteriaceae strains which shifted to ampicillin susceptibility in the presence of sulbactam averaged 68%, but values significantly above or below average were observed in some genera of this family. The percentage of strains which the presence of sulbactam rendered ampicillin-susceptible in vitro reached 97% in Haemophilus strains and 100% in branhamellae and gonococci. High percentages were also recorded in staphylococci, with a peak of 100% in oxacillin-susceptible Staphylococcus aureus strains. In general, center-to-center differences were relatively limited.
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页码:141 / 146
页数:6
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