LOSS OF CONSTITUTIONAL HETEROZYGOSITY IN CHROMOSOME-10 IN HUMAN GLIOBLASTOMA

被引：37
|
作者：
WATANABE, K
NAGAI, M
WAKAI, S
ARAI, T
KAWASHIMA, K
机构：
[1] DOKKYO UNIV,SCH MED,DEPT NEUROSURG,MIBU,TOCHIGI 32102,JAPAN
[2] NATL CANC CTR,RES INST,DIV BIOL,TOKYO 104,JAPAN
来源：
ACTA NEUROPATHOLOGICA | 1990年 / 80卷 / 03期
关键词：
Allelic delection; Malignant gliomas; Restriction fragment length polymorphisms;
D O I：
10.1007/BF00294641
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Gene delection of chromosome 10 in 11 tumor tissues removed from nine patients with malignant glioma (seven glioblastomas and two malignant astrocytomas) was investigated. Loss of heterozygosity was found in four of the seven (57%) cases with glioblastoma, whereas heterozygosity was preserved in two malignant astrocytome cases. One glioblastoma case showed loss of heterozygosity only in the recurring tumor tissue, although heterozygosity was maintained in the initial tumor tissue. The significance of loss of heterozygosity in the growth and recurrence of glioblastoma is discussed. © 1990 Springer-Verlag.
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收藏
页码：251 / 254
页数：4
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