FLUMAZENIL (RO15-1788) DOES NOT AFFECT ETHANOL TOLERANCE AND DEPENDENCE

被引：12

作者：

CHAN, AWK ^{[1
]}

LEONG, FW ^{[1
]}

SCHANLEY, DL ^{[1
]}

LANGAN, MC ^{[1
]}

PENETRANTE, F ^{[1
]}

机构：

[1] SUNY BUFFALO,DEPT PHARMACOL & EXPTL THERAPEUT,BUFFALO,NY 14260

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1991年 / 39卷 / 03期

关键词：

ETHANOL; TOLERANCE; DEPENDENCE; WITHDRAWAL SIGNS; RO15-1788;

D O I：

10.1016/0091-3057(91)90143-P

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

There are conflicting reports concerning whether flumazenil (Ro15-1788) can antagonize the central effects of ethanol and ethanol withdrawal reactions. C57BL/6J mice were treated chronically with an ethanol liquid diet. Control mice were pair fed an isocaloric diet containing no ethanol. These mice were injected with either Ro15-1788 (25 mg/kg) or vehicle immediately before, 14 h or 24 h before ethanol withdrawal. Under these conditions, no attenuation of the severity of handling-induced withdrawal seizures or of withdrawal hypothermia was observed in the ethanol-dependent mice injected with Ro15-1788. Likewise, there was no abolition or attenuation of tolerance to the ataxic effects (sleep time and horizontal dowel tests) and hypothermic effects of ethanol by Ro15-1788 when the mice were tested on day 3 of ethanol withdrawal. It is concluded that Ro15-1788 (25 mg/kg) has no effect on ethanol tolerance and dependence.

引用

页码：659 / 663

页数：5

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