GOSSYPOL AND DERIVATIVES - A NEW CLASS OF ALDOSE REDUCTASE INHIBITORS

被引：47

作者：

DECK, LM ^{[1
]}

VANDERJAGT, DL ^{[1
]}

ROYER, RE ^{[1
]}

机构：

[1] UNIV NEW MEXICO,SCH MED,DEPT BIOCHEM,ALBUQUERQUE,NM 87131

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 34卷 / 11期

关键词：

D O I：

10.1021/jm00115a021

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Gossypol and 17 derivatives were tested as inhibitors of aldose reductase from human placenta. Gossypol and a number of the derivatives were potent inhibitors. The order of inhibitory activity was interpreted in relation to the Kador-Sharpless pharmacophor model for the aldose reductase inhibitor site. The structural but not the electronic aspects of the model were found to apply to this series of compounds.

引用

页码：3301 / 3305

页数：5

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