OPEN-CHAIN PEPTIDES OBTAINED BY ACIDIC HYDROLYTIC CLEAVAGE OF CYCLOSPORINE-A

被引：13
|
作者：
MAGNI, F
ARCELLONI, C
PARONI, R
FERMO, I
BONINI, PA
DELPUPPO, M
MANZOCCHI, A
KIENLE, MG
机构：
[1] UNIV MILAN,DEPT MED CHEM & BIOCHEM,I-20133 MILAN,ITALY
[2] SCI INST HS RAFFAELE,I-20132 MILAN,ITALY
来源：
BIOLOGICAL MASS SPECTROMETRY | 1994年 / 23卷 / 08期
关键词：
D O I：
10.1002/bms.1200230809
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Hydrolysis of cyclosporin A (CsA) was studied in order to clarify the still undefined point of attack of the acidic degradation. Among ether extractable and water-soluble products formed from CsA in HCl, two open-chain peptides were isolated by high-performance liquid chromatography which were identified as the deca- and nonapeptides deriving from CsA through the hydrolytic cleavage of amino acid residue 11 and both residues 11 and 10, respectively. Identification was carried out by fast atom bombardment tandem mass spectrometry.
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页码：514 / 518
页数：5
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