DUOCARMYCINS, POTENT ANTITUMOR ANTIBIOTICS PRODUCED BY STREPTOMYCES SP STRUCTURES AND CHEMISTRY

被引：0

作者：

YASUZAWA, T ^{[1
]}

MUROI, K ^{[1
]}

ICHIMURA, M ^{[1
]}

TAKAHASHI, I ^{[1
]}

OGAWA, T ^{[1
]}

TAKAHASHI, K ^{[1
]}

SANO, H ^{[1
]}

SAITOH, Y ^{[1
]}

机构：

[1] KYOWA HAKKO KOGYO CO LTD, PHARMACEUT RES LABS, NAGAIZUMI, SHIZUOKA 411, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1995年 / 43卷 / 03期

关键词：

STREPTOMYCES SP; ANTITUMOR ANTIBIOTIC; DUOCARMYCIN; EXCITON CHIRALITY;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Seven novel potent antitumor antibiotics, duocarmycins A (1), C1 (2), C2 (3), D (4), B1 (5), B2 (6) and SA (7), were isolated from three independently collected Streptomyces sp. The complete structures, including absolute stereochemistry, were determined by spectral and chemical studies of those duocarmycins and several derivatives. Duocarmycins A (1) and SA (7) possess a 1,2,7,7a-tetrahydrocycloprop[1,2-c]indol-4-one subunit, a common pharmacophore with that of CC-1065 (10) found from Streptomyces zelensis.

引用

页码：378 / 391

页数：14

共 50 条

[1] STRUCTURES OF DUOCARMYCINS, NOVEL ANTITUMOR ANTIBIOTICS PRODUCED BY STREPTOMYCES SP
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[J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 1988, 36 (09) : 3728 - 3731
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NAKANO, H
[J]. JOURNAL OF ANTIBIOTICS, 1991, 44 (10): : 1045 - 1053
[3] Antitumor antibiotics: Duocarmycins
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[J]. Chemistry of Heterocyclic Compounds, 1998, 34 (12) : 1386 - 1405
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