SYNTHESIS OF +/--CARBOCYCLIC ANALOG OF SPIROHYDANTOIN NUCLEOSIDE

被引：49
|
作者：
SANO, H
SUGAI, S
机构：
[1] Agroscience Research Laboratories, Sankyo Co. Ltd., Yasu-gun, Shiga-ken, 520-23
来源：
TETRAHEDRON | 1995年 / 51卷 / 16期
关键词：
D O I：
10.1016/0040-4020(95)00162-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Synthesis of (+/-)-carbocyclic spirohydantoin derivatives of (+)-hydantocidin is described. The pivotal step in the synthesis is spirohydantoin ring construction from cyclopentanone 9. Using the Bucherer-Bergs condition predominately gave the epi-carbocyclic analogue 10, whereas the alternative spiroring formation method through alpha-aminonitrile 13 provided the carbocyclic analogue 2 after deprotection.
引用
收藏
页码：4635 / 4646
页数：12
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