Targeting Receptors, Transporters and Site of Absorption to Improve Oral Drug Delivery

被引:0
|
作者
Hamman, J. H. [1 ]
Demana, P. H. [1 ]
Olivier, E. I. [1 ]
机构
[1] Tshwane Univ Technol, Sch Pharm, Private Bag X680, ZA-0001 Pretoria, South Africa
来源
DRUG TARGET INSIGHTS | 2007年 / 2卷
关键词
Oral drug delivery; absorption enhancement; receptor-mediated endocytosis; active transporters; site-specific drug delivery;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Although the oral route of drug administration is the most acceptable way of self-medication with a high degree of patient compliance, the intestinal absorption of many drugs is severely hampered by different biological barriers. These barriers comprise of biochemical and physical components. The biochemical barrier includes enzymatic degradation in the gastrointestinal lumen, brush border and in the cytoplasm of the epithelial cells as well as effl ux transporters that pump drug molecules from inside the epithelial cell back to the gastrointestinal lumen. The physical barrier consists of the epithelial cell membranes, tight junctions and mucus layer. Different strategies have been applied to improve the absorption of drugs after oral administration, which range from chemical modifi cation of drug molecules and formulation technologies to the targeting of receptors, transporters and specialized cells such as the gut-associated lymphoid tissues. This review focuses specifi cally on the targeting of receptor-mediated endocytosis, transporters and the absorption-site as methods of optimizing intestinal drug absorption. Intestinal epithelial cells express several nutrient transporters that can be targeted by modifying the drug molecule in such a way that it is recognized as a substrate. Receptor-mediated endocytosis is a transport mechanism that can be targeted for instance by linking a receptor substrate to the drug molecule of interest. Many formulation strategies exist for enhancing drug absorption of which one is to deliver drugs at a specifi c site in the gastrointestinal tract where optimum drug absorption takes place.
引用
收藏
页码:71 / 81
页数:11
相关论文
共 50 条
  • [1] Targeting Membrane Transporters for Oral Drug Delivery
    Swaan, Peter W.
    BIOPHYSICAL REVIEWS, 2021, 13 (06) : 1476 - 1476
  • [2] Targeting Intestinal Transporters for Optimizing Oral Drug Absorption
    Varma, Manthena V.
    Ambler, Catherine M.
    Ullah, Mohammad
    Rotter, Charles J.
    Sun, Hao
    Litchfield, John
    Fenner, Katherine S.
    El-Kattan, Ayman F.
    CURRENT DRUG METABOLISM, 2010, 11 (09) : 730 - 742
  • [3] Targeting Transporters for CNS Drug Delivery
    Ronaldson, Patrick T.
    CURRENT PHARMACEUTICAL DESIGN, 2014, 20 (10) : 1419 - 1421
  • [4] Evaluation of Three Amorphous Drug Delivery Technologies to Improve the Oral Absorption of Flubendazole
    Vialpando, Monica
    Smulders, Stefanie
    Bone, Scott
    Jager, Casey
    Vodak, David
    Van Speybroeck, Michiel
    Verheyen, Loes
    Backx, Katrien
    Boeykens, Peter
    Brewster, Marcus E.
    Ceulemans, Jens
    de Armas, Hector Novoa
    Van Geel, Katrien
    Kesselaers, Emma
    Hillewaert, Vera
    Lachau-Durand, Sophie
    Meurs, Greet
    Psathas, Petros
    Van Hove, Ben
    Verreck, Geert
    Voets, Marieke
    Weuts, Ilse
    Mackie, Claire
    JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 105 (09) : 2782 - 2793
  • [5] Targeting approaches to oral drug delivery
    Lambkin, I
    Pinilla, C
    EXPERT OPINION ON BIOLOGICAL THERAPY, 2002, 2 (01) : 67 - 73
  • [6] Oral drug delivery utilizing intestinal OATP transporters
    Tamai, Ikumi
    ADVANCED DRUG DELIVERY REVIEWS, 2012, 64 (06) : 508 - 514
  • [7] Significance of intestinal drug efflux transporters for oral absorption
    Warhurst, G.
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 2005, 57 : S116 - S117
  • [8] Targeting Inflammation to Improve Tumor Drug Delivery
    Gkretsi, Vasiliki
    Zacharia, Lefteris C.
    Stylianopoulos, Triantafyllos
    TRENDS IN CANCER, 2017, 3 (09): : 621 - 630
  • [9] Targeting platelet function to improve drug delivery
    Demers, Melanie
    Wagner, Denisa D.
    ONCOIMMUNOLOGY, 2012, 1 (01) : 100 - 102
  • [10] An Oral Human Drug Absorption Study to Assess the Impact of Site of Delivery on the Bioavailability of Bevirimat
    Connor, Alyson
    Evans, Phil
    Doto, Judy
    Ellis, Corey
    Martin, David E.
    JOURNAL OF CLINICAL PHARMACOLOGY, 2009, 49 (05): : 606 - 612