DEVELOPMENTAL EFFECTS OF MONENSIN ON DROSOPHILA-MELANOGASTER

被引：1

作者：

CALLAERTS, P ^{[1
]}

DELOOF, A ^{[1
]}

机构：

[1] KATHOLIEKE UNIV LEUVEN,INST ZOOL,B-3000 LOUVAIN,BELGIUM

来源：

ROUXS ARCHIVES OF DEVELOPMENTAL BIOLOGY | 1993年 / 203卷 / 1-2期

关键词：

DROSOPHILA; MONENSIN; EXTRACELLULAR MATRIX; MEMBRANE PROTEINS; MORPHOGENESIS;

D O I：

10.1007/BF00539893

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Extracellular matrix and membrane proteins and their correct secretion probably are key elements in morphogenesis and differentiation in Drosophila. in this study, we have analysed the effects of monensin, a Na+-H+-ionophore which blocks normal secretion, applied during cellular blastoderm formation on further development. Normal cell morphology and intercellular contacts are lost and the extracellular matrix becomes disorganized. Gastrulation is blocked and abnormal foldings can be observed. Cuticle phenotypes showed different degrees of ventral, dorsal, head and posterior defects. The results are discussed in the context of what is known about membrane and extracellular matrix proteins in Drosophila.

引用

页码：83 / 91

页数：9

共 50 条

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