Evaluation of In-vitro Antiproliferative Potency and In-vivo Induced Biochemical Parameters of Curcin from Jatropha curcas seed in Comparison to Doxorubicin and Cisplatin

Plants are promising sources of new bioactive compounds that mostly showed less side effects. The aim of this study is to evaluate in vitro antiproliferative Potency and in vivo induced biochemical parameters of curcin extracted from Jatropha curcas seeds in comparison to Cisplatin and Doxorubicin. In vitro antiproliferative potency of curcin towards human promyelocytic leukemia (HL-60), lung (A549), breast (T-47D, MCF-7), colon (LoVo) and liver (HepG2) cancer cell lines were investigated. In vivo studies were carried on albino rats to investigate the effect of curcin on different biochemical parameters. Results showed that the highest in vitro cytotoxic activity of curcin was towards HL-60, MCF-7 and HepG2 cell lines (IC50 3.67, 3.12 and 4.9 mu g/ml respectively). On the other hand, results of the biochemical investigations indicated that Cisplatin and Doxorubicin caused significant changes in the level of all parameters tested while treatment with curcin showed slight, moderate or no significant changes.