RELEASE OF KETOPROFEN FROM MICROSPHERES OF POLY (2-HYDROXYETHYL METHACRYLATE) OR POLY (2-HYDROXYETHYL METHACRYLATE)-CO-BETA-METHACRYLOYLOXYETHYL DEOXYCHOLATE CROSS-LINKED WITH ETHYLENE-GLYCOL DIMETHACRYLATE AND TETRAETHYLENE GLYCOL DIMETHACRYLATE

This study analyses the effect of deoxycholic acid covalently bound to the monomer on loading levels and release kinetics of ketoprofen from poly (2-hydroxyethyl methacrylate), ethylene glycol dimethacrylate or tetraethylene glycol dimethacrylate crosslinked microspheres. The micelling agent in the polymeric structure increases loading levels of ketoprofen both in loading by soaking and by drug incorporation in the reaction mixture. The release kinetics approach zero order both during and after swelling and the slowest release rates are observed from poly (2-hydroxyethyl methacrylate)-co-beta-methacryloyloxyethyl deoxycholate, ethylene glycol dimethacrylate crosslinked microspheres loaded by drug incorporation in the reaction mixture.