EFFECT OF SODIUM PENTOSAN POLYSULFATE ON TISSUE-LIPIDS IN CONTROL AND GLYCOLATE TREATED RATS

Sodium pentosan polysulphate (SPP) has been reported to have a lipid lowering action. In addition it has been shown to prevent calcium oxalate crystallization in vitro and in vivo. Hence it was felt worthwhile to study the effect of SPP on altered tissue lipid levels, manifested in hyperoxaluric condition during glycollate feeding in rats. Elevated cholesterol with reduced phospholipid levels in both liver and kidney tissues, were the significant observations in the experimental animals. In addition total lipids were increased in the kidney. Administration of SPP to hyperoxaluric rats reduced tissue cholesterol and triglyceride levels significantly and raised the phospholipid levels in the tissues. Cholesterol ester synthetase (CES) and cholesterol ester hydrolase (CEH) activities were also assayed in the liver. Glycollate fed rats exhibited increased CES activity. SPP treatment had a lowering effect on CES but enhanced the CEH activity in both control and glycollate administered rats. The alterations may have a bearing in relation to calcium oxalate stone formation. © 1993 Academic Press. All rights reserved.