The Role of Inflammation in the Pathogenesis of Colorectal Cancer

被引：70
|
作者：
McConnell, Beth B. [1 ]
Yang, Vincent W. [1 ]
机构：
[1] Emory Univ, Sch Med, Dept Med, Div Digest Dis, 201 Whitehead Res Bldg,615 Michael St, Atlanta, GA 30322 USA
来源：
CURRENT COLORECTAL CANCER REPORTS | 2009年 / 5卷 / 02期
关键词：
D O I：
10.1007/s11888-009-0011-z
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Chronic inflammatory disorders are often associated with an increased risk of developing cancer. A classic example of the connection between inflammation and cancer is the increased risk of colorectal cancer in patients with inflammatory bowel disease (IBD). In this review, we discuss aspects of IBD that promote colorectal cancer and highlight key molecular mediators that contribute to cancer risk. Additionally, we report on progress in identifying molecular targets that may prove efficacious in blocking the progression of IBD-related inflammation to cancer.
引用
收藏
页码：69 / 74
页数：6
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