AMNIOTIC-FLUID PLATELET FACTOR-IV AND BETA-THROMBOGLOBULIN

被引：0
|
作者：
SALEH, AA
OZAWA, T
DOMBROWSKI, MP
ISADA, NB
JOHNSON, MP
EVANS, MI
BOTTOMS, SF
MAMMEN, EF
机构：
[1] Center for Fetal Diagnosis and Therapy, Departments of Obstetrics and Gynecology, Molecular Biology and Genetics, Hutzel Hospital, Wayne State University, Detroit, MI
来源：
FETAL DIAGNOSIS AND THERAPY | 1993年 / 8卷 / 03期
关键词：
PLATELET ACTIVATING FACTOR; PLATELET FACTOR-IV; BETA-THROMBOGLOBULIN; GENETIC AMNIOCENTESIS; PULMONARY MATURITY AMNIOCENTESIS;
D O I：
10.1159/000263817
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Platelet activating factor (PAF), a powerful platelet activator, has been identified in huma embryos and fetuses, and may induce fetal lung maturation. The potential effect of PAF on fetal platelets as indicated by release of beta-thromboglobulin (BTG) and platelet factor 4 (PF4) has not been investigated. We measured BTG and PF4 in amniotic fluid from 78 genetic and 35 pulmonary maturity amniocenteses. BTG and PF4 were higher in the genetic amniocentesis samples (p < 0.001 in each case) than in the lung maturity samples. BTG and PF4 did not correlate with the pulmonary maturity parameters as measured by the lecithin to sphingomyelin ratio and phosphatidylglycerol concentration. Our findings suggest a fetal origin of BTG and PF4 in amniotic fluid.
引用
收藏
页码：165 / 167
页数：3
相关论文
共 50 条
  • [1] AMNIOTIC-FLUID PLATELET FACTOR-IV AND BETA-THROMBOGLOBULIN AS MARKERS OF STRUCTURAL ABNORMALITIES
    SALEH, AA
    OZAWA, T
    ISADA, NB
    JOHNSON, MP
    DOMBROWSKI, MP
    EVANS, MI
    TREADWELL, MB
    MAMMEN, EF
    [J]. FETAL DIAGNOSIS AND THERAPY, 1993, 8 (03) : 175 - 177
  • [2] ELISA EVALUATION OF BETA-THROMBOGLOBULIN AND PLATELET FACTOR-IV
    AMIRAL, J
    TREBAOL, JF
    ADAM, M
    [J]. THROMBOSIS RESEARCH, 1986, : 170 - 170
  • [3] BETA-THROMBOGLOBULIN AND PLATELET FACTOR-IV LEVELS IN PREGNANCY AND PREECLAMPSIA
    AYHAN, A
    AKKOK, E
    URMAN, B
    YARALI, H
    DUNDAR, S
    KIRAZLI, S
    [J]. GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 1990, 30 (01) : 12 - 14
  • [4] CHARACTERIZATION OF THE HUMAN BETA-THROMBOGLOBULIN GENE - COMPARISON WITH THE GENE FOR PLATELET FACTOR-IV
    MAJUMDAR, S
    GONDER, D
    KOUTSIS, B
    PONCZ, M
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1991, 266 (09) : 5785 - 5789
  • [5] CONTAINERS FOR BETA-THROMBOGLOBULIN (BETA-TG) AND PLATELET FACTOR-IV (PF-4)
    OHNO, Y
    OKADA, T
    [J]. THROMBOSIS AND HAEMOSTASIS, 1993, 69 (06) : 701 - 701
  • [6] PLASMA BETA-THROMBOGLOBULIN AND PLATELET FACTOR-IV CONCENTRATIONS IN PATIENTS WITH ATRIAL-FIBRILLATION
    YAMAUCHI, K
    FURUI, H
    TANIGUCHI, N
    SOTOBATA, I
    [J]. JAPANESE HEART JOURNAL, 1986, 27 (04): : 481 - 487
  • [7] PLATELET-AGGREGATION, CIRCULATING PLATELET AGGREGATES, BETA-THROMBOGLOBULIN AND PLATELET FACTOR-IV IN CHILDHOOD HEADACHE
    OREFICE, G
    CARRIERI, PB
    AMATI, C
    DESIMONE, R
    NOLANO, M
    ULLUCCI, E
    FARACE, A
    SORGE, F
    [J]. HEADACHE IN CHILDREN AND ADOLESCENTS, 1989, 833 : 213 - 216
  • [8] BETA-THROMBOGLOBULIN LEVELS IN AMNIOTIC-FLUID OF PATIENTS WITH INTRAAMNIOTIC INFECTIONS
    SALEH, AA
    HIROKAWA, S
    ROMERO, R
    YOON, BH
    GOMEZ, R
    SOROKIN, Y
    MAMMEN, EF
    [J]. THROMBOSIS AND HAEMOSTASIS, 1993, 69 (06) : 566 - 566
  • [9] BETA-THROMBOGLOBULIN (BETA-TG) AND PLATELET FACTOR-IV (PF4) IN HEAVY DRINKERS
    BRIANZONI, E
    BERBELLINI, A
    CECCANTI, M
    DONATO, G
    PENNESI, M
    CENTIONI, G
    MASCIANGELO, R
    [J]. JOURNAL OF NUCLEAR MEDICINE AND ALLIED SCIENCES, 1987, 31 (01): : 33 - 33
  • [10] BETA-THROMBOGLOBULIN AND PLATELET FACTOR-IV IN THE FOLLOW-UP OF ACUTE MYELOFIBROSIS (MEGAKARYOBLASTIC LEUKEMIA)
    BERNAL, LP
    DIEZ, IG
    [J]. MEDICINA CLINICA, 1990, 95 (01): : 21 - 24
12345