DETERMINATION OF ACIPIMOX IN CAPSULES BY DIFFERENTIAL-PULSE POLAROGRAPHY

被引：1
|
作者：
MICHELITSCH, A
MUHR, P
SCHUBERTZSILAVECZ, M
LIKUSSAR, W
机构：
[1] Institut für Pharmazeutische Chemie, Universität Graz, Graz, A-8010
来源：
MIKROCHIMICA ACTA | 1995年 / 118卷 / 3-4期
关键词：
ACIPIMOX; DETERMINATION OF; DPP; POLAROGRAPHY;
D O I：
10.1007/BF01244354
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A differential pulse polarographic (DPP) method has been developed for the determination of acipimox in its pharmaceutical formulations. Using Sorensen buffer pH 6.0 as supporting electrolyte a single, irreversible peak occurred at - 0.79 V vs an Ag/AgCl reference electrode. The peak height vs concentration plot was found to be linear over the range of 10(-6) to 6 x 10(-4)mol/l. The detection limit is 60 ng/ml. The analysis of a series of 10 Olbetam(R) 250 mg capsules showed an overall standard deviation of +/- 4.18 mg and a S-rel of +/- 1.66%, respectively.
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页码：147 / 152
页数：6
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