EFFECTS OF HYPOXIA AND HYPERCAPNIA ON THE FORCE VELOCITY RELATION OF RABBIT MYOCARDIUM

被引:11
|
作者
WALLEY, KR
FORD, LE
WOOD, LDH
机构
[1] UNIV CHICAGO,CARDIOL SECT,CHICAGO,IL 60637
[2] UNIV CHICAGO,PULM & CRIT CARE MED SECT,CHICAGO,IL 60637
关键词
HYPOXIA; HYPERCAPNIA; RESPIRATORY ACIDOSIS; MAXIMUM POWER; MYOCARDIAL FORCE-VELOCITY RELATION; MAXIMUM VELOCITY OF SHORTENING;
D O I
10.1161/01.RES.69.6.1616
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The separate effects of hypoxia and hypercapnia on the force-velocity relation of rabbit myocardium were compared in 10 papillary or trabecular muscles superfused using control (95% O2-5% CO2), hypoxic (18% O2), and hypercapnic (200% CO2) physiological salt solutions. This level of hypoxia did not irreversibly damage the muscles and reduced peak isometric force by 53 +/- 11%. The level of hypercapnia was chosen to match the force depression (50 +/- 12%) produced by hypoxia. Multiple force-velocity points were measured by applying critically damped isotonic force steps at 90% of the time to peak isometric force and at the time to 50% peak isometric force. These points defined the force-velocity relation and maximum velocity of shortening, the extrapolated isometric force, and the maximum power of nonpotentiated and postextrasystolic potentiated contractions. Hypoxia and hypercapnia reduced maximum force and maximum power nearly equally. Maximum velocity of shortening decreased more during hypoxia (21 +/- 12%) than during hypercapnia (12 +/- 9%) (p < 0.01). Postextrasystolic potentiation completely reversed the reduction of maximum velocity of shortening during hypercapnia but not during hypoxia. A 6% internal load could account for the reduction in maximum velocity of shortening during hypercapnia and all but 9% of the reduction in maximum velocity of shortening during hypoxia. The relative time course of the force-velocity relation was not altered by either hypoxia or hypercapnia. We conclude that hypercapnia reduces the effect of activation because increased activation (by postextrasystolic potentiation) restored the force-velocity relation and maximum velocity of shortening to control values. In contrast, hypoxia results in a small but significant additional reduction of maximum velocity of shortening. This suggests an additional effect of hypoxia on the contractile proteins, indicating decreased maximum rate of actomyosin ATPase cycling. Maximum power was decreased only by the force effects and not by the velocity effects of hypoxia and hypercapnia.
引用
收藏
页码:1616 / 1625
页数:10
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