KINETICS OF ONSET OF RATE-DEPENDENT EFFECTS OF CLASS-I ANTI-ARRHYTHMIC DRUGS ARE IMPORTANT IN DETERMINING THEIR EFFECTS ON REFRACTORINESS IN GUINEA-PIG VENTRICLE, AND PROVIDE A THEORETICAL BASIS FOR THEIR SUBCLASSIFICATION

被引：359

作者：

CAMPBELL, TJ ^{[1
]}

机构：

[1] UNIV OXFORD, DEPT PHARMACOL, OXFORD OX1 3QT, ENGLAND

来源：

CARDIOVASCULAR RESEARCH | 1983年 / 17卷 / 06期

关键词：

D O I：

10.1093/cvr/17.6.344

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：344 / 352

页数：9

共 12 条

[1] Kinetics of onset of rate-dependent effects of Class I antiarrhythmic drugs are important in determining their effects on refractoriness in guinea-pig ventricle, and provide a theoretical basis for their subclassification
Campbell, TJ
CARDIOVASCULAR RESEARCH, 2000, 45 (01) : 53 - 54
[2] IMPORTANCE OF PHYSICOCHEMICAL PROPERTIES IN DETERMINING THE KINETICS OF THE EFFECTS OF CLASS-I ANTI-ARRHYTHMIC DRUGS ON MAXIMUM RATE OF DEPOLARIZATION IN GUINEA-PIG VENTRICLE
CAMPBELL, TJ
BRITISH JOURNAL OF PHARMACOLOGY, 1983, 80 (01) : 33 - 40
[3] DIFFERING EFFECTS OF CLASS-I ANTI-ARRHYTHMIC DRUGS ON VENTRICULAR REFRACTORINESS ARE PARTLY DETERMINED BY THEIR KINETICS OF INTERACTION WITH SODIUM-CHANNELS
CAMPBELL, TJ
AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE, 1983, 13 (04): : 410 - 411
[4] INTERVAL-DEPENDENT EFFECTS OF SMALL ANTI-ARRHYTHMIC DRUGS ON EXCITABILITY OF GUINEA-PIG MYOCARDIUM
COURTNEY, KR
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1980, 12 (11) : 1273 - 1286
[5] FREQUENCY AND VOLTAGE DEPENDENT EFFECTS OF AN-132, A NEW CLASS-I ANTI-ARRHYTHMIC AGENT, ON VMAX OF ACTION-POTENTIAL UPSTROKE IN GUINEA-PIG VENTRICULAR MUSCLES
CHIHARA, S
KODAMA, I
TOYAMA, J
CARDIOVASCULAR RESEARCH, 1988, 22 (09) : 648 - 655
[6] STEADY-STATE AND RATE DEPENDENT EFFECTS OF ANTI-ARRHYTHMIC DRUGS ON VMAX AND CONDUCTION-VELOCITY IN GUINEA-PIG PAPILLARY-MUSCLE
BUCHANAN, JW
GETTES, LS
CIRCULATION, 1983, 68 (04) : 295 - 295
[7] Kinetics of rate-dependent shortening of action potential duration in guinea-pig ventricle;: effects of IK1 and IKr blockade
Williams, BA
Dickenson, DR
Beatch, GN
BRITISH JOURNAL OF PHARMACOLOGY, 1999, 126 (06) : 1426 - 1436
[8] Comparison of the effects of class I anti-arrhythmic drugs, cibenzoline, mexiletine and flecainide, on the delayed rectifier K+ current of guinea pig ventricular myocytes
Wang, DW
Kiyosue, T
Sato, T
Arita, M
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1996, 28 (05) : 893 - 903
[9] RATE-DEPENDENT EFFECTS OF THE CLASS-I ANTIARRHYTHMIC DRUGS LIDOCAINE, QUINIDINE, PRAJMALINE AND PROPAFENONE ON THE ACTION-POTENTIAL DURATION IN ATRIUM AND VENTRICLE - NEW ASPECTS OF THE SUBCLASSIFICATION IN CLASS-IA, CLASS-B AND CLASS-C
LANGENFELD, H
KOHLER, C
KOCHSIEK, K
HERZ KREISLAUF, 1990, 22 (08): : 298 - 301
[10] A MODEL STUDY OF TIME-DEPENDENT AND VOLTAGE-DEPENDENT EFFECTS OF CLASS-I ANTIARRHYTHMIC DRUGS IN GUINEA-PIG PAPILLARY-MUSCLES AS RELATED TO EXTERNAL POTASSIUM CONCENTRATION
HAMAMOTO, T
KOJIMA, M
MATSUZAKI, M
KUSUKAWA, R
BAN, T
ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 1994, 44-2 (08): : 929 - 937

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