Synthesis and Antimicrobial Evaluation of Certain Novel Thiazoles

被引：7

作者：

Sreedevi, Meesaraganda ^{[1
]}

Prasad, Aluru Raghavendra Guru ^{[2
]}

Spoorthy, Yadati Narasimha ^{[1
]}

Ravindranath, Lakshmana Rao Krishna Rao ^{[1
]}

机构：

[1] Sri Krishnadevaraya Univ, Anantapur, Andhra Pradesh, India

[2] ICFAI Fdn Higher Educ, Hyderabad, Andhra Pradesh, India

来源：

ADVANCED PHARMACEUTICAL BULLETIN | 2013年 / 3卷 / 01期

关键词：

Imidazole moiety; Thiazole moiety; Synthesis; Characterization; Antimicrobial activity;

D O I：

10.5681/apb.2013.037

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Purpose: This article makes an attempt to synthesize certain compounds containing thiazole and imidazole moieties and screen for the antimicrobial properties. Methods: The novel compounds synthesized were characterized by elemental analysis, IR and 1HNMR spectral data. The antimicrobial activity of novel compounds was evaluated by cup plate method. Results: The compound p-t showed more antibacterial activity than that of the standard. p-hp and p-as showed considerable antibacterial activity. p-t demonstrated higher antifungal activity than that of the standard while p-hp and p-as showed considerable antifungal activity. Conclusion: The antimicrobial activity studies were conducted on certain selected bacteria and fungi. In each case antimicrobial activity of the compounds was compared with that of standards. p-t, p-hp, p-np, p-cp, p-ts and pas showed considerable antimicrobial activity.

引用

页码：227 / 230

页数：4

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