INHIBITION OF ALLOXAN-INDUCED HYPERGLYCEMIA IN MICE BY THE PYRIDOINDOLE STOBADINE

被引：14
|
作者：
STEFEK, M
TRNKOVA, Z
机构：
[1] Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava
来源：
PHARMACOLOGY & TOXICOLOGY | 1995年 / 77卷 / 05期
关键词：
D O I：
10.1111/j.1600-0773.1995.tb01034.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Alloxan-induced hyperglycaemia was used as a model of free radical pathology to test the antioxidant activity of the pyridoindole drug, stobadine, in the intact mouse. Stobadine was injected intraperitoneally in a dose range 7.5-60 mg/kg prior to intravenous injection of alloxan (50 mg/kg), and blood glucose concentration 72 hr after alloxan administration was used as an index of alloxan toxicity. Stobadine efficiently suppressed the alloxan-induced hyperglycaemia in a dose-dependent manner. This protection against the diabetogenic effect of alloxan is consistent with the high efficacy of stobadine to scavenge hydroxyl radicals.
引用
收藏
页码：320 / 322
页数：3
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