ASYMMETRIC-SYNTHESIS .31. SYNTHESIS OF 2-SUBSTITUTED PIPERAZINES FROM CHIRAL NON-RACEMIC LACTAMS

被引：41
|
作者：
SCHANEN, V
RICHE, C
CHIARONI, A
QUIRION, JC
HUSSON, HP
机构：
[1] UNIV PARIS 05,FAC SCI PHARMACEUT & BIOL,CNRS,CHIM THERAPEUT LAB,F-75270 PARIS 06,FRANCE
[2] CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVETTE,FRANCE
来源：
TETRAHEDRON LETTERS | 1994年 / 35卷 / 16期
关键词：
ASYMMETRIC SYNTHESIS; 2-SUBSTITUTED PIPERAZINES; DIASTEREOSELECTIVE ALKYLATION OF LACTAMS;
D O I：
10.1016/S0040-4039(00)77163-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The preparation of lactam 2 from R-(-)-phenylglycinol and N-Boc glycine is described. Diastereoselective alkylation of 2 allowed the preparation of piperazine derivatives in an optically pure form.
引用
收藏
页码：2533 / 2536
页数：4
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