IN-VITRO RELEASE AND PERMEATION KINETICS OF PENTAZOCINE FROM MATRIX-DISPERSION TYPE TRANSDERMAL DRUG-DELIVERY SYSTEMS

被引：10
|
作者：
MANDAL, SC [1 ]
BHATTACHARYYA, M [1 ]
GHOSAL, SK [1 ]
机构：
[1] UNIV JADAVPUR,DEPT PHARMACEUT TECHNOL,CALCUTTA 700032,INDIA
来源：
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1994年 / 20卷 / 11期
关键词：
D O I：
10.3109/03639049409050220
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A matrix-dispersion type Transdermal Drug Delivery System (TDS) of Pentazocine (PZ) was fabricated, using combinations of rate controlling polymers, namely Eudragits RS100 (RS), RL100 (RL), Ethylcellulose (EC) and Polyvinyl pyrrolidone (PVP), with the objective of examining the effects bf formulation variables on drug-permeation profiles. In depth in-vitro drug release and skin-permeation kinetics with three different loads, and also the effects of combination of Isopropyl Myristate (IPM), as permeation enhancer, were studied using male albino mice abdominal skin. The release of PZ over a 12 hour period followed Higuchi kinetics, while in-vitro mice-skin permeation of PZ followed an apparent Zero-order kinetics over a period of 24 hours.
引用
收藏
页码：1933 / 1941
页数：9
相关论文
共 50 条
  • [1] STUDIES ON CORRELATION BETWEEN IN-VITRO SKIN PERMEATION OF PENTAZOCINE THROUGH MOUSE AND HUMAN CADAVER SKINS FROM TRANSDERMAL DRUG-DELIVERY SYSTEMS
    MANDAL, SC
    MANDAL, M
    GHOSAL, SK
    [J]. STP PHARMA SCIENCES, 1994, 4 (06): : 477 - 481
  • [2] RELEASE AND PERMEATION KINETICS OF MATRIX-TYPE TRANSDERMAL DELIVERY SYSTEMS FOR VERAPAMIL
    TOJO, K
    CHIEN, YW
    [J]. JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, 1989, 22 (06) : 689 - 691
  • [3] Release and permeation kinetics of matrix-type transdermal delivery systems for verapamil
    [J]. Tojo, Kakuji, 1600, (22):
  • [4] IN-VITRO EVALUATION OF TRANSDERMAL DRUG-DELIVERY
    SHAH, VP
    LESKO, LJ
    WILLIAMS, RL
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 1995, 41 (03) : 163 - 167
  • [5] ADHESIVE MATRIX TYPE TRANSDERMAL DRUG-DELIVERY SYSTEM FOR NITROGLYCERIN
    PAI, RM
    DESAI, MS
    BABTIWALE, AD
    SHRIVASTAVA, R
    [J]. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1994, 20 (11) : 1905 - 1909
  • [6] Development of matrix controlled transdermal delivery systems of pentazocine: In vitro/in vivo performance
    Verma, Priya Ranjan Prasad
    Chandak, Ashok R.
    [J]. ACTA PHARMACEUTICA, 2009, 59 (02) : 171 - 186
  • [7] DEVELOPMENT AND IN-VITRO EVALUATION OF CHITOSAN-BASED TRANSDERMAL DRUG-DELIVERY SYSTEMS FOR THE CONTROLLED DELIVERY OF PROPRANOLOL HYDROCHLORIDE
    THACHARODI, D
    RAO, KP
    [J]. BIOMATERIALS, 1995, 16 (02) : 145 - 148
  • [8] Liquid Crystalline Systems for Transdermal Delivery of Celecoxib: In Vitro Drug Release and Skin Permeation Studies
    Estracanholli, Eder Andre
    Praca, Fabiola Silva Garcia
    Cintra, Ana Beatriz
    Riemma Pierre, Maria Bernadete
    Lara, Marilisa Guimaraes
    [J]. AAPS PHARMSCITECH, 2014, 15 (06): : 1468 - 1475
  • [9] Liquid Crystalline Systems for Transdermal Delivery of Celecoxib: In Vitro Drug Release and Skin Permeation Studies
    Éder André Estracanholli
    Fabíola Silva Garcia Praça
    Ana Beatriz Cintra
    Maria Bernadete Riemma Pierre
    Marilisa Guimarães Lara
    [J]. AAPS PharmSciTech, 2014, 15 : 1468 - 1475
  • [10] In vitro drug release of composite matrix transdermal delivery system
    Jiang, Guoqiang
    Chen, Jun
    Wang, Yong
    Ma, Jianguo
    Zhu, Dequan
    Ding, Fuxin
    [J]. Qinghua Daxue Xuebao/Journal of Tsinghua University, 2002, 42 (10): : 1317 - 1319
12345