ROLE OF ZINC IN INTERLEUKIN-2 (IL-2)-MEDIATED T-CELL ACTIVATION

被引：46
|
作者：
TANAKA, Y [1 ]
SHIOZAWA, S [1 ]
MORIMOTO, I [1 ]
FUJITA, T [1 ]
机构：
[1] KOBE UNIV,SCH MED,DEPT MED,DIV 3,KOBE 650,JAPAN
来源：
SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1990年 / 31卷 / 05期
关键词：
D O I：
10.1111/j.1365-3083.1990.tb02805.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In a serum‐free culture containing no zinc, zinc enhanced the proliferation of T cells in response to interleukin 2 (lL‐2), and also the in vitro production of lL‐2 by T cells. Although the lymphocyte proliferation was partially inhibited by anti‐IL‐2 antibodies, it was completely inhibited by anti‐IL‐2 receptor (CD25) antibodies. A Scatchard plot analysis showed that zinc induced the expression of high‐affinity receptors for IL‐2 on lymphocytes. The results indicated that zinc may be essentially required for IL‐2‐mediated T‐cell activation. Copyright © 1990, Wiley Blackwell. All rights reserved
引用
收藏
页码：547 / 552
页数：6
相关论文
共 50 条
  • [1] HUMAN T-CELL HYBRIDOMAS SECRETING INTERLEUKIN-2 (IL-2)
    FOON, K
    ROSSIO, J
    SCHROFF, R
    ABRAMS, P
    RAGER, H
    CLARKE, G
    PICKERAL, S
    FIDLER, I
    PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1983, 24 (MAR): : 220 - 220
  • [2] RETROVIRAL ACTIVATION OF THE INTERLEUKIN-2 (IL-2) GENE IN A GIBBON APE T-CELL LINE
    DURAND, DB
    KAMOUN, M
    NORRIS, CA
    GREENGARD, JS
    KANT, JA
    CRABTREE, GR
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1986, : 164 - 164
  • [3] RECOMBINANT INTERLEUKIN-2 (IL-2) PROMOTES T-CELL LINE-MEDIATED NEUROAUTOIMMUNE DISEASE
    SCHLUESENER, HJ
    LASSMANN, H
    JOURNAL OF NEUROIMMUNOLOGY, 1986, 11 (01) : 87 - 91
  • [4] INTERLEUKIN-2 (IL-2) ADMINISTERED INVIVO - INFLUENCE OF IL-2 ROUTE AND TIMING ON T-CELL GROWTH
    CHEEVER, MA
    THOMPSON, JA
    KERN, DE
    GREENBERG, PD
    JOURNAL OF IMMUNOLOGY, 1985, 134 (06): : 3895 - 3900
  • [5] MOLECULAR MECHANISM OF THE INTERLEUKIN-2(IL-2) PRODUCTION DEFECT IN T-CELL ANERGY
    BEVERLY, B
    KANG, SM
    BRORSON, KA
    TRAN, A
    LENARDO, MJ
    SCHWARTZ, RH
    FASEB JOURNAL, 1992, 6 (04): : A1408 - A1408
  • [6] INTERLEUKIN-2 (IL-2) AND IL-2 RECEPTOR - RELATIONSHIPS TO DEFECTIVE T-CELL PROLIFERATION IN ACQUIRED IMMUNODEFICIENCY SYNDROMES (AIDS)
    PRINCE, HE
    GOTTLIEB, MS
    KERMANIARAB, V
    FAHEY, JL
    FEDERATION PROCEEDINGS, 1983, 42 (05) : 1334 - 1334
  • [7] STUDIES ON INTERLEUKIN-2 RECEPTOR EXPRESSION AND IL-2 PRODUCTION BY MURINE T-CELL LYMPHOMAS
    DIAMANTSTEIN, T
    OSAWA, H
    GRAF, L
    SCHIRRMACHER, V
    BRITISH JOURNAL OF CANCER, 1985, 51 (01) : 23 - 30
  • [8] GROWTH OF AKR T-CELL LEUKEMIA LYMPHOBLASTS IN MEDIUM CONTAINING INTERLEUKIN-2 (IL-2)
    SHIH, CY
    TRUITT, RL
    ANDREANI, M
    BORTIN, MM
    IN VITRO-JOURNAL OF THE TISSUE CULTURE ASSOCIATION, 1983, 19 (10): : 759 - 766
  • [9] EFFECTS OF HYPERLIPEMIC SERUM ON INTERLEUKIN-2 (IL-2) PRODUCTION, IL-2 RECEPTOR EXPRESSION, AND T-CELL PROLIFERATION INDUCED BY IL-2 IN CYNOMOLGUS MONKEYS
    TERAO, K
    FUKASE, Y
    JAPANESE JOURNAL OF MEDICAL SCIENCE & BIOLOGY, 1991, 44 (01): : 17 - 28
  • [10] ROLE OF IL-2 AND IL-4 IN T-CELL ACTIVATION - SPECIFIC CONTROL OF IL-2 RECEPTOR EXPRESSION BY IL-2
    JANKOVIC, DL
    GIBERT, M
    BARAN, D
    THEZE, J
    LYMPHOKINE RESEARCH, 1988, 7 (03): : 316 - 316
12345