COMPLEMENT ALLOTYPES IN FAMILIAL AND SPORADIC ALZHEIMERS-DISEASE

被引：3
|
作者：
PANEGYRES, PK
DAWKINS, RL
机构：
[1] WESTMEAD HOSP,DEPT NEUROL,WESTMEAD,NSW 2145,AUSTRALIA
[2] ROYAL PERTH HOSP,DEPT CLIN IMMUNOL,PERTH,WA 6000,AUSTRALIA
来源：
JOURNAL OF NEUROLOGY | 1991年 / 238卷 / 06期
关键词：
FAMILIAL ALZHEIMERS DISEASE; SPORADIC ALZHEIMERS DISEASE; COMPLEMENT ALLOTYPES;
D O I：
10.1007/BF00315331
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
To resolve conflicting findings on the association of complement allotypes with Alzheimer's disease (AD) we have studied the C4 phenotypes in 33 sporadic cases and in one family with familial AD. We found no association with complement alleles in familial or sporadic AD, even though a familial case had absence of the C4 null allele (C4BQ0). Our data do not suggest a role for complement genes in the pathogenesis of AD. It also seems that the C4B2 allele cannot be used as a marker for AD as has been suggested by others.
引用
收藏
页码：325 / 326
页数：2
相关论文
共 50 条
  • [1] A COMPARISON OF FAMILIAL AND SPORADIC ALZHEIMERS-DISEASE
    DUARA, R
    LOPEZALBEROLA, RF
    BARKER, WW
    LOEWENSTEIN, DA
    ZATINSKY, M
    EISDORFER, CE
    WEINBERG, GB
    [J]. NEUROLOGY, 1993, 43 (07) : 1377 - 1384
  • [2] COMPLEMENT C-4 ALLOTYPES IN ALZHEIMERS-DISEASE
    NERL, CW
    MAYEUX, R
    ONEILL, GJ
    [J]. LANCET, 1982, 2 (8311): : 1343 - 1343
  • [3] FAMILIAL ALZHEIMERS-DISEASE VERSUS SPORADIC ALZHEIMERS-DISEASE - A CLINICAL, NEUROPSYCHOLOGICAL AND PET STUDY
    KENNEDY, AM
    NEWMAN, SN
    WARRINGTON, EK
    ROQUES, P
    FRACKOWIAK, RSJ
    ROSSOR, MN
    [J]. NEUROLOGY, 1993, 43 (04) : A192 - A192
  • [4] CLINICAL SPECIFICITY OF FAMILIAL AND SPORADIC FORMS OF ALZHEIMERS-DISEASE
    GAVRILOVA, SI
    VOSKRESENSKAYA, NI
    TRUBNIKOV, VI
    [J]. ZHURNAL NEVROPATOLOGII I PSIKHIATRII IMENI S S KORSAKOVA, 1990, 90 (09): : 38 - 43
  • [5] MOLECULAR PATHOLOGY OF ALZHEIMERS-DISEASE IN SPORADIC AND FAMILIAL ALZHEIMERS-DISEASE WITH MUTATIONS IN THE AMYLOID PRECURSOR PROTEIN
    HANGER, DP
    MANN, DMA
    NEARY, D
    ANDERTON, BH
    [J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 1992, 20 (03) : 642 - 645
  • [6] COMPARISON OF THE SEVERITY OF NEUROPATHOLOGIC CHANGES IN FAMILIAL AND SPORADIC ALZHEIMERS-DISEASE
    NOCHLIN, D
    VANBELLE, G
    BIRD, TD
    SUMI, SM
    [J]. ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 1993, 7 (04): : 212 - 222
  • [7] APOE ALLELE FREQUENCIES IN ITALIAN SPORADIC AND FAMILIAL ALZHEIMERS-DISEASE
    SORBI, S
    NACMIAS, B
    FORLEO, P
    LATORRACA, S
    GOBBINI, I
    BRACCO, L
    PIACENTINI, S
    AMADUCCI, L
    [J]. NEUROSCIENCE LETTERS, 1994, 177 (1-2) : 100 - 102
  • [8] SPORADIC AND FAMILIAL ALZHEIMERS-DISEASE - ONE CLINICAL ENTITY OR 2
    BRACCO, L
    GIORGI, C
    LIPPI, A
    TONINI, S
    AMADUCCI, L
    [J]. ANNALS OF NEUROLOGY, 1988, 24 (01) : 134 - 134
  • [9] FAMILIAL ALZHEIMERS-DISEASE
    SADOVNICK, AD
    TUOKKO, H
    HORTON, A
    BAIRD, PA
    BEATTIE, BL
    [J]. CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 1988, 15 (02) : 142 - 146
  • [10] FAMILIAL ALZHEIMERS-DISEASE
    ROSSOR, MN
    [J]. BAILLIERES CLINICAL NEUROLOGY, 1992, 1 (03): : 517 - 534
12345