SISTER CHROMATID EXCHANGES, PROLIFERATING RATE INDEX, AND MICRONUCLEI IN BIOMONITORING OF INTERNAL EXPOSURE TO VINYL-CHLORIDE MONOMER IN PLASTIC INDUSTRY WORKERS

被引：26

作者：

SINUES, B ^{[1
]}

SANZ, A ^{[1
]}

BERNAL, ML ^{[1
]}

TRES, A ^{[1
]}

ALCALA, A ^{[1
]}

LANUZA, J ^{[1
]}

CEBALLOS, C ^{[1
]}

SAENZ, MA ^{[1
]}

机构：

[1] UNIV SARAGOSSA,SCH MED,DEPT ONCOL,ZARAGOZA,SPAIN

来源：

TOXICOLOGY AND APPLIED PHARMACOLOGY | 1991年 / 108卷 / 01期

关键词：

D O I：

10.1016/0041-008X(91)90266-H

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The frequency of micronuclei (MN), sister chromatid exchange (SCEs), and the proliferating rate index in peripheral blood lymphocytes from 93 individuals were measured. Fifty-two of the individuals were workers in the plastics industry where they were exposed to vinyl chloride monomer while the remaining 41 individuals served as a control group. In our results, an increase of SCEs and MN, as well as inhibited cell kinetics, was observed in the group of exposed workers. Of the tests used, SCE was found to be the most sensitive endpoint for indicating a biological response. However, since methods for restricting the MN analysis to only cells at risk (i.e., second generation interphase cells) were not used, this statement requires verification. © 1991.

引用

页码：37 / 45

页数：9

共 7 条

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Vaglenov, A
Lalchev, S
Nosko, M
Sabeva, J
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CYTOGENETICS AND CELL GENETICS, 1999, 85 (1-2): : 103 - 103
[2] THE PERSISTENCE OF SISTER-CHROMATID EXCHANGE FREQUENCIES IN MEN OCCUPATIONALLY EXPOSED TO VINYL-CHLORIDE MONOMER
FUCIC, A
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DIMITROVIC, B
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MUTATION RESEARCH, 1992, 281 (02): : 129 - 132
[3] CHROMOSOMAL ANALYSIS IN VINYL-CHLORIDE EXPOSED WORKERS - COMPARISON OF THE STANDARD TECHNIQUE WITH THE SISTER-CHROMATID EXCHANGE TECHNIQUE
ANDERSON, D
RICHARDSON, CR
PURCHASE, IFH
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MUTATION RESEARCH, 1981, 83 (01): : 137 - 144
[4] CORRELATION BETWEEN EXPOSURE TO STYRENE AND THE FREQUENCY OF CHROMOSOMAL-ABERRATIONS AND SISTER-CHROMATID EXCHANGES IN LYMPHOCYTES OF WORKERS IN A PLASTIC BOAT FACTORY
UGGLA, AH
ANDERSSON, HC
TRANBERG, EA
ZETTERBERG, LG
MUTATION RESEARCH, 1980, 74 (03): : 199 - 199
[5] SISTER-CHROMATID EXCHANGES, CHROMOSOME-ABERRATIONS, PROLIFERATING RATE INDEX AND URINARY THIOETHERS IN PATIENTS UNDERGOING LONG-TERM THERAPY WITH CARBAMAZEPINE
BERNAL, ML
GAZULLA, J
SAENZ, MA
LANUZA, J
BARTOLOME, M
SINUES, B
MUTATION RESEARCH, 1992, 271 (02): : 188 - 188
[6] XRCC1, CYP2E1 and ALDH2 genetic polymorphisms and sister chromatid exchange frequency alterations amongst vinyl chloride monomer-exposed polyvinyl chloride workers
Ruey-Hong Wong
Jung-Der Wang
Ling-Ling Hsieh
Tsun-Jen Cheng
Archives of Toxicology, 2003, 77 : 433 - 440
[7] XRCC1, CYP2E1 and ALDH2 genetic polymorphisms and sister chromatid exchange frequency alterations amongst vinyl chloride monomer-exposed polyvinyl chloride workers
Wong, RH
Wang, JD
Hsieh, LL
Cheng, TJ
ARCHIVES OF TOXICOLOGY, 2003, 77 (08) : 433 - 440

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