ALPHA-1-ANTITRYPSIN DEFICIENCY AND LIVER-DISEASE

被引：12
|
作者：
PROPST, T
PROPST, A
DIETZE, O
JUDMAIER, G
BRAUNSTEINER, H
VOGEL, W
机构：
[1] Department of Internal Medicine, Innsbruck University
来源：
DIGESTIVE DISEASES | 1994年 / 12卷 / 03期
关键词：
ALPHA-1-ANTITRYPSIN DEFICIENCY; LIVER DISEASE;
D O I：
10.1159/000171447
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Alpha-1-antitrypsin deficiency is a common autosomal recessive disorder associated with premature development of emphysema, liver cirrhosis and hepatocellular carcinoma. This article reviews the existing literature on alpha-1-antitrypsin deficiency, with an emphasis on recent developments. A description of the protein, gene structure and function of alpha-1-antitrypsin as well as clinical aspects are presented. Treatment issues are addressed and a framework for the diagnostic workup and management of patients with alpha-1-antitrypsin deficiency and chronic liver disease is provided.
引用
收藏
页码：139 / 149
页数：11
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