MOLLUSCICIDAL SAPONINS FROM PHYTOLACCA-DODECANDRA

被引：20
|
作者：
THIILBORG, ST
CHRISTENSEN, SB
CORNETT, C
OLSEN, CE
LEMMICH, E
机构：
[1] DANISH BILHARZIASIS LAB,JAEGERSBORG ALLE 1D,DK-2920 CHARLOTTENLUND,DENMARK
[2] ROYAL VET & AGR UNIV,DEPT CHEM,DK-1871 FREDERIKSBERG,DENMARK
[3] ROYAL DANISH SCH PHARM,DEPT ORGAN CHEM,DK-2100 COPENHAGEN,DENMARK
来源：
PHYTOCHEMISTRY | 1993年 / 32卷 / 05期
关键词：
PHYTOLACCA-DODECANDRA; PHYTOLACCACEAE; ENDOD STRAIN 44; ENDOD-S; MOLLUSCICIDES; TRITERPENOID SAPONINS; OLEANOLIC ACID;
D O I：
10.1016/S0031-9422(00)95085-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new monodesmosidic saponins were isolated from an aqueous extract of the Ethiopian strain 44 of Phytolacca dodecandra. Their structures were established as 3-0-{alpha-L-rhamnopyranosyl-(1-->2)-O-[beta-D-galactopyranosyl-(1-->3)]-beta-D-glucopyranosyl}oleanolic acid and 3-O-{beta-D-xylopyranosyl-(1-->6)-O-beta-D-gluco-pyranosyl-(1-->3)]-beta-D-glucopyranosyl}oleanolic acid mainly by spectroscopic methods (LSIMS, H-1 NMR, COSY, NOESY, TOCSY, J-resolved H-1 NMR, C-13 NMR, HETCOR). The saponins are potent molluscicides against the schistosomiasis transmitting snail Biomphalaria glabrata with LC50 values of 2 and 5 ppm, respectively.
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收藏
页码：1167 / 1171
页数：5
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