CHRONIC ETHANOL ADMINISTRATION ALTERS BINDING OF [S-35] T-BUTYLBICYCLOPHOSPHOROTHIONATE TO THE GABA BENZODIAZEPINE RECEPTOR COMPLEX IN RAT-BRAIN

被引：7

作者：

HILLMANN, M ^{[1
]}

WILCE, PA ^{[1
]}

PIETRZAK, ER ^{[1
]}

WARD, LC ^{[1
]}

SHANLEY, BC ^{[1
]}

机构：

[1] UNIV QUEENSLAND,DEPT BIOCHEM,ALCOHOL RES UNIT,ST LUCIA,QLD 4067,AUSTRALIA

来源：

NEUROCHEMISTRY INTERNATIONAL | 1990年 / 16卷 / 02期

关键词：

D O I：

10.1016/0197-0186(90)90086-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chronic treatment of male Wistar rats with ethanol (15% v/v) in drinking fluid for a period of 3 months affected the binding of the chloride channel antagonist, [35S]TBPS, to well-washed synaptic membranes and slide-mounted brain slices, the affinity for [35S]TBPS in brains of ethanol-treated animals was significantly decreased in comparison to controls while receptor density was increased (P < 0.001). However, other well described treatments, viz. an ethanol-containing liquid diet and chronic inhalation of ethanol failed to demonstrate changes in the binding of [35S]TBPS in brain preparations. Our findings suggest that long-term administration of ethanol can induce alterations in the characteristics of the ionophore component of the GABA-benzodiazepine receptor complex. This may have relevance to ethanol-induced neuronal damage. © 1990.

引用

页码：187 / 191

页数：5

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