QUALITY-CONTROL IN MANUFACTURING PROCESS BY NEAR-INFRARED SPECTROSCOPY

被引：26
|
作者：
GONZALEZ, F
POUS, R
机构：
[1] Quality Control Department, Laboratorios Almirall, S.A. Crta. Nacional II, E-08740 Barcelona, Km 593, Sant Andreu de la Barca
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1995年 / 13卷 / 4-5期
关键词：
NEAR INFRARED SPECTROSCOPY (NIR); QUALIFICATION; C-PLOT; DISPLOPT; PHARMACEUTICAL; ROUTINE ANALYSIS; PATTERN RECOGNITION TECHNIQUE;
D O I：
10.1016/0731-7085(95)01333-G
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The combination of a pattern recognition technique with near infrared spectroscopy (NIR) to determine the conformity of a pharmaceutical mixture can be used in the routine checking of a pharmaceutical product. All the chemical and physical characteristics of the product that influence the NIR spectrum affect the qualification. The qualification is used to determine several deviations in the process: moisture, particle size and non-homogeneity. This work presents a method for the qualification analysis of a pharmaceutical mixture using the standard software of the instrument and a new program (DISPLOT). This program allows the acquisition of the plot of the scaled distances with its sign vs the wavelength.
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页码：419 / 423
页数：5
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