NUCLEOTIDE-SEQUENCE OF GENES HRDA, HRDC, AND HRDD FROM STREPTOMYCES-COELICOLOR A3(2) HAVING SIMILARITY TO RPOD GENES

被引：33
|
作者：
TANAKA, K
SHIINA, T
TAKAHASHI, H
机构：
[1] Institute of Applied Microbiology, University of Tokyo, Bunkyo-ku, Tokyo
来源：
MOLECULAR & GENERAL GENETICS | 1991年 / 229卷 / 03期
关键词：
PRINCIPAL SIGMA FACTOR; RPOD GENES; SEQUENCE HOMOLOGY; STREPTOMYCES-COELICOLOR; OPEN READING FRAME;
D O I：
10.1007/BF00267453
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The complete nucleotide sequences were determined of hrdA, hrdC, and hrdD from Streptomyces coelicolor A3(2). They indicate the presence of a single open reading frame in each gene coding for polypeptides of 396 (43747 daltons), 339 (38173 daltons), and 332 amino acid residues (37190 daltons), respectively. These amino acid sequences revealed extensive similarities with the principal sigma factors of Bacillus subtilis, Escherichia coli, Myxococcus xanthus, Pseudomonas aeruginosa, and also the katF gene product of E. coli. Besides the highly conserved amino acid residues in the "rpoD box " region, alignment of hrd gene products and the known principal sigma factors and sigma-related factors allowed us to postulate a common basic structure for the principal sigma type factors as distinct from the alternative sigma factors.
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页码：334 / 340
页数：7
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