ROLE OF ENDOTHELIN IN THE EXERCISE INTOLERANCE OF CHRONIC HEART-FAILURE

被引：74
|
作者：
KRUM, H
GOLDSMITH, R
WILSHIRECLEMENT, M
MILLER, M
PACKER, M
机构：
[1] COLUMBIA UNIV,COLL PHYS & SURG,DIV CIRCULATORY PHYSIOL,CTR HEART FAILURE RES,NEW YORK,NY
[2] MT SINAI MED CTR,NEW YORK,NY 10029
来源：
AMERICAN JOURNAL OF CARDIOLOGY | 1995年 / 75卷 / 17期
关键词：
D O I：
10.1016/S0002-9149(99)80783-8
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In conclusion, plasma levels of the endothelialderived vasoconstrictor endothelin-1 (but not those of other neurohormonal vasoconstrictor factors), measured during exercise correlated closely with objective variables of exercise capacity in patients with heart failure. These findings suggest that endothelin-1 may contribute to exercise intolerance in patients with heart failure, perhaps by limiting the ability of the peripheral vasculature to dilate during exercise. © 1995 Excerpta Medica, Inc. All rights reserved.
引用
收藏
页码：1282 / 1283
页数：2
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