Visceral larva migrans (VLM) is endemic in Israel; therefore, a positive serology is not unusual in our general population. The clinical manifestations of the disease may mimic other clinical conditions. Sometimes life-threatening disorders have to be considered in the differential diagnosis. This diagnostic dilemma can be solved occasionally only by histological examination. We report two patients, one with a lymphoma-like presentation and the other with an intraocular tumoral mass suggesting retinoblastoma, and discuss the diagnostic difficulties.