TRANSFORMATION OF GRAYANOTOXIN-II/GRAYANOTOXIN-II TETRAACETATE TO 1,5-SECO GRAYANOTOXIN DERIVATIVES

被引：0
|
作者：
TERAI, T
NISHIOKU, Y
GOTO, K
机构：
[1] Department of Applied Chemistry, Osaka Institute of Technology, Osaka 535, Omiya 5-16-1, Asahi-ku
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1994年 / 58卷 / 12期
关键词：
D O I：
10.1271/bbb.58.2251
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Oxidation of grayanotoxin (GTX) II with lead (IV) acetate in methanol gave a new derivative, the 1(R)-spiro-3,6(S),14,16-tetrahydroxy-5-keto derivative. Treatment of GTX-II tetraacetate in acetic acid by using Pb(IV) acetate as an oxidizing agent gave a novel 1,5-seco-GTX derivative, Delta(1(10))-1,5-seco-GTX-pentaacetate, together with the 1,5-seco-GTX-1(R) derivative. Oxidation of GTX-II-tetraacetate with Tl(III)) acetate in acetic acid or benzene gave the 1,5-seco-GTX-1(S) derivative.
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页码：2251 / 2253
页数：3
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