2-ALKYL-4-ETHYL-5-[6-METHYL-6-(2H-TETRAZOL-5-YL)HEPTYLOXY]PHENOL LEUKOTRIENE B-4 RECEPTOR ANTAGONISTS

被引：4
|
作者：
SOFIA, MJ
NELSON, K
HERRON, DK
GOODSON, T
FROELICH, LL
SPAETHE, SM
MARDER, P
ROMAN, CR
FLEISCH, JH
机构：
[1] Lilly Research Laboratories, Eli Lilly and Co., Indianapolis
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 17期
关键词：
D O I：
10.1016/0960-894X(95)00340-Y
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 2-n-alkyl-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl) heptyloxy]phenols were prepared and shown to be potent leukotriene B-4 (LTB(4)) receptor antagonists. They bound to the human neutrophil and guinea pig lung. LTB(4) receptors with high affinity. Each compound was also shown to be effective at antagonizing the effects of LTB(4)-induced integrin up-regulation on human neutrophils and on LTB(4)-mediated contraction of guinea pig lung parenchyma.
引用
收藏
页码：1995 / 2000
页数：6
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