HPLC and GLC determination of residual solvents in busulphan

被引：7
|
作者：
Kalchenko, OI
Golub, VA
Zavatskaja, IV
机构：
[1] Institute of Organic Chemistry, Ukrainian Academy of Sciences
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1995年 / 14卷 / 1-2期
关键词：
busulphan; ethanol; pyridine; HPLC; GLC;
D O I：
10.1016/0731-7085(95)01617-1
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Quantitative methods using HPLC and GLC for the determination of residual pyridine and ethanol in busulphan have been developed. The measurement errors for pyridine and ethanol in busulphan samples (p = 0.95) were found to be 10% and 7%. It was shown that one recrystallization enabled pure busulphan to be prepared.
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页码：107 / 111
页数：5
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