PRODUCTION OF HUMAN INTERFERON-BETA BY SENDAI VIRUS AND POLY(RI).POLY(RC) - INHIBITION BY NEOMYCIN

被引：2
|
作者：
LIN, HY
DAVIS, PJ
THACORE, HR
机构：
[1] SUNY BUFFALO,SCH MED & BIOMED SCI,DEPT MICROBIOL,218 SHERMAN HALL,BUFFALO,NY 14214
[2] SUNY BUFFALO,SCH MED & BIOMED SCI,DEPT MED,BUFFALO,NY 14214
来源：
JOURNAL OF INTERFERON RESEARCH | 1991年 / 11卷 / 06期
关键词：
D O I：
10.1089/jir.1991.11.365
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neomycin inhibits the production of interferon-beta (IFN-beta) in human fibroblast cells in response to Sendai virus or to poly(rI).poly(rC) in a concentration-dependent manner, and to the greatest extent effective when added prior to or up to 2 h after induction. This inhibitory effect is negated when the protein kinase C activator, SC-9, is present during IFN-beta production in response to poly(rI).poly(rC), but not in response to Sendai virus. These results suggest that in human cells both virus and poly(rI).poly(rC) utilize an early neomycin-sensitive signal transduction step for the production of IFN-beta; because neomycin binds specific phosphatidylinositol phosphates, both of these inducers very likely require hydrolysis of these phosphates.
引用
收藏
页码：365 / 369
页数：5
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