A SINGLE PREEXPOSURE PRODUCES SENSITIZATION TO THE LOCOMOTOR EFFECTS OF COCAINE IN MICE

被引：58
|
作者：
JACKSON, HC [1 ]
NUTT, DJ [1 ]
机构：
[1] SCH MED SCI,DEPT PHARMACOL,RECKITT & COLMAN PSYCHOPHARMACOL UNIT,BRISTOL BS8 1TD,ENGLAND
来源：
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1993年 / 45卷 / 03期
关键词：
COCAINE; LOCOMOTOR ACTIVITY; SENSITIZATION (2-DAY PARADIGM); CONDITIONING; ENVIRONMENT-DEPENDENT MICE;
D O I：
10.1016/0091-3057(93)90533-Y
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Sensitization to the locomotor effects of cocaine (10 mg/kg, IP) occurred in mice following preexposure to a single high dose (40 mg/kg, IP) of the drug on the previous day. Behavioral sensitization only occurred under certain experimental conditions; that is, in mice which were injected in a novel environment (i.e., the activity boxes) on day 1 and tested in the same environment on day 2. It did not occur in mice that were fully habituated to the test apparatus on both days of the experiment or in mice that were injected in the home cage on day 1. This model is consistent with studies in rats, and offers the opportunity for further characterization of the processes underlying cocaine sensitization.
引用
收藏
页码：733 / 735
页数：3
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